You want to install some application or software but prior to that you are required to use windows update so that the software is supported with the system and when you run windows update you end up with error 646 or 0x80070646, this error indicates that the installer have encountered a problem. This error causes due to the invalid entry in registry.
You may surely be choosing the option 'Try again' to install the updates, if in case it doesn't work try by 'disabling ' your anti-virus software and 'turn off' the firewall, it might be revoking some access to it. This step can turn out to be helpful. If it still doesn't work then making changes in Registry will get it done.
Before moving to next step it is necessary to back up your registry file.
Now,
From the program list right click regedit.exe and then select Run as administrator. If it prompts for password, type your administrator password or click continue.
Click on the Right-Arrow on computer then HKEY_USERS → .Default → Software → Microsoft → Windows → CurrentVersion → Explorer → User Shell Folders.
In the details pane of the registry window, Locate AppData.
The value of this key should be %USERPROFILE%\AppData\Roaming.

If the value is not set as %USERPROFILE%\AppData\Roaming then right click on AppData and select Modify.
Set the value to USERPROFILE%\AppData\Roaming into the box and then hit Ok.
Close the registry.
If the problem still persists then make the same changes in the following registry field.
HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folder.
HKEY_MACHINE\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folder.
For the Window-XP User, to open the registry file you will have to type regedit.exe in Run box.
This should get your update running without throwing any error.
Don't forget to back up your registry file.
Related article: DVD drive is missing, delete upper and lower filter from registry file.
Before moving to next step it is necessary to back up your registry file.
Now,
Click start and type regedit in search box.
From the program list right click regedit.exe and then select Run as administrator. If it prompts for password, type your administrator password or click continue.
Click on the Right-Arrow on computer then HKEY_USERS → .Default → Software → Microsoft → Windows → CurrentVersion → Explorer → User Shell Folders.
In the details pane of the registry window, Locate AppData.
The value of this key should be %USERPROFILE%\AppData\Roaming.

If the value is not set as %USERPROFILE%\AppData\Roaming then right click on AppData and select Modify.
Set the value to USERPROFILE%\AppData\Roaming into the box and then hit Ok.
Close the registry.
If the problem still persists then make the same changes in the following registry field.
HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folder.
HKEY_MACHINE\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folder.
For the Window-XP User, to open the registry file you will have to type regedit.exe in Run box.
This should get your update running without throwing any error.
Don't forget to back up your registry file.
Related article: DVD drive is missing, delete upper and lower filter from registry file.




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